Arthrofibrosis of the knee is a devastating complication after injury or surgery, but the astute clinician should be able to recognise the warning signs in time to prevent long term issues.
First published by Dr Noyes in 2008, and reviewed August 2023 by Dr Sheila Strover (Clinical Editor)
Arthrofibrosis is a complication of knee injury or surgery where an excessive scar tissue response leads to painful restriction of knee flexion, extension, or both.
The scar tissue may form intra-articularly (within the joint) and extra-articularly (outside the joint, in soft tissue spaces) and persists despite routine rehabilitation and knee motion exercises.
Defining Arthrofibrosis
In this course I will try and help delegates understand the precipitating causes, the danger signals, and the early and late management of this potentially disastrous disorder.
In arthrofibrosis the ROM loss is due to disordered healing -
- adhesions stretching across the joint spaces maturing into fibrous tissue
- this fibrous tissue slowly contracting to pull these spaces closed
- the fibrous tissue thickening the joint capsule and slowly contracting to tighten it up.
The loss of range of motion is secondary to this fibrous over-response. As we progress through this course, I will explain to you the set of symptoms and signs which make one suspicious that the cause of a limited ROM is indeed arthrofibrosis and not something else.
What makes the knee vulnerable to arthrofibrosis?
Certain conditions tend to make the knee vulnerable to arthrofibrosis -
- the original injury itself - for example a fracture near the joint, injury complicated by haemarthrosis, multiple ligament injury (especially if both ACL and PCL are torn), dislocation of the knee, infection, inflammation (synovitis), associated meniscal tears, disruption of the extensor mechanism (tibial tubercle avulsion, quadriceps rupture, patellar tendon rupture, patellar fracture).
- the treatment - for example arthroplasty, anterior cruciate ligament graft too tight or poorly positioned, poor timing of graft procedure, high tibial osteotomy, prolonged immobilisation in a cast
- post-op complications - for example post-op haemarthrosis (eg after lateral release), inflammation, synovitis, infection, RSD
- the rehabilitation - for example prolonged immobilisation, poor rehabilitation programme, poor adherence to rehabilitation
Arthrofibrosis triggered by such conditions is referred to as secondary arthrofibrosis, as the scarring is a local phenomenon and not part of a generalised healing disorder. However, arthrofibrosis can also be triggered without these predisposing conditions in patients who have a general problem with scar tissue biology, and who tend normally to produce excessive scar tissue in response to any injury or surgery anywhere in the body. In these cases, the arthrofibrosis is termed primary arthrofibrosis. The cause of primary arthrofibrosis is not yet known, but the current assumption is that it is genetically-determined. Investigators are currently studying patients with primary arthrofibrosis to determine if they can identify the guilty gene or genes (eg ref 2). Of course, a person with the primary predisposition may be unfortunate enough to suffer also from one of the high risk conditions.
How common is arthrofibrosis?
The incidence of arthrofibrosis is fortunately decreasing as clinicians become better at understanding and preventing the full-blown disorder. A survey of the medical literature published over the last twenty years provides us with some idea of the current size of the problem, in at least some of the conditions I have mentioned.
A review of the literature suggests that stiffness after total knee replacement occurs in about 1% of cases (ref 3).
Arthrofibrosis is the most common complication of ACL reconstruction (ref 4). In the 1980's, ACL reconstruction was associated with incidences of arthrofibrosis of approximately 19%, and in some studies was reported to be as high as 35% (ref 5). The loss of motion from the arthrofibrosis was often more disabling than the original instability for which the surgery had been performed. Currently, with improved understanding and changes in surgical timing and technique and rehabilitation, the incidence for this procedure is less than 10%. In our Center, a focus on immediate knee motion and early management of extension and flexion limitations after ACL reconstruction has shown our rate to be less than 1% in major studies conducted on over 600 patients (refs 6-8).
Many early publications reported an unacceptably high incidence of arthrofibrosis after high tibial osteotomy. Windsor and colleagues, for example, in 1988 reported that 80% of their patients developed patella infera following closing wedge high tibial osteotomy with cast immobilisation. Some ten years later Westrich and colleagues were able to show greatly reduced incidences when patients were mobilised early, without a prolonged period in a cast. In our experience, immediate knee motion begun the day following either closing or opening wedge osteotomy has resulted in a 0% incidence of arthrofibrosis (refs 9-11).
It is not easy to determine the incidence of arthrofibrosis triggered purely by immobilisation, as a plaster cast is usually applied in association with another problem, which may in itself be a trigger, eg patellar fracture. Suffice it to say that the trend in knee surgery is to minimise immobilisation to avoid arthrofibrosis.
References
1 Shelbourne KD, Patel DV, Martini DJ. Classification and management of arthrofibrosis of the knee after anterior cruciate ligament reconstruction. American Journal of Sports Medicine, 1996;24(6): 857-862.
2 Skutek M, Elsner HA, Slateva K, Mayr HO, Weig TG, van Griensven M, Krettek C, Bosch U. Screening for arthrofibrosis after anterior cruciate ligament reconstruction: analysis of association with human leukocyte antigen. Arthroscopy. 2004 May;20(5):469-73.
3 Hutchinson JRM, Parish EN, Cross MJ. Results of open arthrolysis for the treatment of arthrofibrosis following uncemented total knee arthroplasty. http://www.kneeclinic.com.au/papers/documents/Arthrolysis1.pdf
4 Coolican MRJ. Revision anterior cruciate ligament reconstruction - causes of failure. http://www.isakos.com/meetings/1999congress/coolican.html
5 DeHaven KE, Cosgarea AJ, Sebastianelli WJ. Arthrofibrosis of the Knee Following Ligament Surgery. Instr Course Lect 2003;52:369-381
6 Noyes FR, Mangine RE, Barber SD. Early knee motion after open and arthroscopic anterior cruciate ligament reconstruction. Am J Sports Med 1987;15:149-160
7 Noyes FR, Mangine RE, Barber SD. Early treatment of motion complications following anterior cruciate ligament surgery. Clin Orthop 1992;277;217-228
8 Noyes FR, Berrios-Torres S, Barber-Westin SD, Heckmann TP: Prevention of permanent arthrofibrosis after anterior cruciate ligament reconstruction alone or combined with associated procedures: A prospective study in 443 knees. Knee Surg, Spts Traumat, Arthr 2000;8:196-206
9 Noyes FR, Mayfield W, Barber-Westin SD, Albright J, Heckmann T. Opening wedge high tibial osteotomy: An operative technique and rehabilitation program to decrease complications and promote early union and function. Am J Sports Med 2006;Feb. 21 (Epub ahead of print)
10 Noyes FR, Barber-Westin SD, Hewett TE. High tibial osteotomy and ligament reconstruction for varus angulated anterior cruciate ligament deficient knees. Am J Sports Med 2000;28:282-296
11 Noyes FR, Barber SD, Simon R: High tibial osteotomy and ligament reconstruction in varus angulated, anterior cruciate ligament-deficient knees. A two to seven year follow-up study. Am J Sports Med 1993;21:2-12
INTRODUCTION: Arthrofibrosis - course
NEXT PART: The knee - range of motion