An orthobiologic helps injuries to heal by using cell-based therapies and biological materials that will become part of repaired but living tissue.


What kinds of orthobiologic are commonly used?

The materials may be:


Discussion looking at the alternatives to a joint replacement in active patients whose osteoarthritis tends to be limited.

A discussion of newer concepts in fat-derived stem cell work.

A comparison of different types of knee injection.

An overview of current stem cell practice relating to the knee and a hint of the future.

The Editor's interpretation of a 2011 book chapter published in the book 'Modern Arthroscopy'.

Biologic Knee Replacement

A course by knee surgeon, Dr Kevin R Stone M.D. of the Stone Clinic in San Francisco, California, USA.



Orthobiologics and platelet rich plasma. Dhillon MS, Behera P, Patel S, and Shetty V. Indian J Orthop. 2014 Jan-Feb; 48(1): 1–9.

Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates. Moatshe G, Morris ER, Cinque ME, Pascual-Garrido C, Chahla J, Engebretsen L and Laprade RF. Acta Orthop. 2017 Nov; 88(6): 670–674.

See also:


eBook - The Magic of Fat Cells

A discussion by Professor Paul Lee about the changes one sees in osteoarthritis of the knee, and the role of regenerative medicine and surgery in improving the status of the joint cartilage in an effort to delay, or even prevent, knee replacement.