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A mesenchymal stem cell is a multipotent progenitor cell that can be isolated and expanded from various sources and which can help to repair and rebuild tissues.

mesenchymal stem cell
Here, progenitor cells called pericytes which hug the tiny blood vessels transform into mesenchymal stem cells, which themselves can then transform into various more differentiated cells, such as myocytes (to make muscle) or chondrocytes (to make cartilage).

 

The value of mesenchymal stem cells (MSCs)

Isolated from various adult tissues, mesenchymal stem cells cannot differentiate into all types of cells, but can differentiate into several types of cells belonging to our skeletal tissues, such as cartilage, bone and fat. Besides this multilineage potential, MSCs secrete chemicals that regulate the microenvironment of tissues - this is called immunomodulation - and they can secrete anti-inflammatory substances as well.

Synonyms: 
MSC
Medicinal signalling cell
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A discussion of newer concepts in fat-derived stem cell work.

An overview of current stem cell practice relating to the knee and a hint of the future.

The Editor's interpretation of a 2011 book chapter published in the book 'Modern Arthroscopy'.

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CLINICAL PUBLICATIONS

The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells—Their Current Uses and Potential Applications. Berebichez-Fridman R, Gómez-García R, Granados-Montiel J, Berebichez-Fastlicht E, Olivos-Meza A, Granados J, Velasquillo C and Ibarra C. Stem Cells Int. 2017; 2017: 2638305.

Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development. Tremolada C, Colombo V and Ventura C. Curr Stem Cell Rep. 2016; 2(3): 304–312.

Immunomodulation by Mesenchymal Stromal Cells and Their Clinical Applications. Cagliani J, Grande D, Molmenti EP, Miller EJ and Rilo HLR. J Stem Cell Regen Biol. 2017; 3(2): 10.15436/2471-0598.17.022.

Human mesenchymal stem cells - current trends and future prospective Ullah I, Subbarao RB and Rho GJ. Biosci Rep. 2015; 35(2): e00191.


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Webinar - The Magic of Fat Cells.