Microfragmented fat is a preparation of fat which has been aspirated from an area of the body like the front of the abdomen and passed through a system to chop it up and extract the portion that contains progenitor cells.

fat matrix of cells, vessels and precursor cells    
The microfragmented fat contains fat cells, tiny vessels and precursor cells.    


How microfragmented fat is used in the knee

Under local anaesthesia, the doctor aspirates with a large syringe fat from the fatty part of the abdomen or thighs. After microfragmentation, the useful portion of the aspirate is injected into the knee.


A discussion of newer concepts in fat-derived stem cell work.



Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development. Tremolada C, Colombo V and Ventura C. Curr Stem Cell Rep. 2016; 2(3): 304–312.

Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction. Vezzani B, Shaw I, Lesme H, Yong L, Khan N, Tremolada C and Péault B. Stem Cells Translational Medicine, Volume7, Issue12, 876-886.

Micro-fragmented adipose tissue for treatment of knee osteoarthritis with Baker’s cyst: a case study. Arthurs JR, Desmond CM, TerKonda SP and Shapiro SA. BMJ Case Rep. 2018; 2018: bcr2018224426.

See also -


The Magic of Fat Cells - ebook