Microfragmented fat is a preparation of fat which has been aspirated from an area of the body like the front of the abdomen and passed through a system to chop it up and extract the portion that contains progenitor cells.

fat matrix of cells, vessels and precursor cells
The microfragmented fat contains fat cells, tiny vessels and precursor cells that cling to the vessels.


How microfragmented fat is used in the knee

Under local anaesthesia, the doctor aspirates with a large syringe fat from the fatty part of the abdomen or thighs. After microfragmentation, the useful portion of the aspirate is injected into the knee. The progenitor cells, called pericytes, migrate off the tiny vessels and enter the tissues where they may transform into mesenchymal stem cells and play a part in healing and repair.


The Magic of Fat Cells

Link to ebook download

A discussion of newer concepts in fat-derived stem cell work.



Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development. Tremolada C, Colombo V and Ventura C. Curr Stem Cell Rep. 2016; 2(3): 304–312.

Metabolomic changes in human adipose tissue derived products following non-enzymatic microfacturing. Garcia-Contreras M, Messaggio F, Mendez AJ and Ricordi C. Eur Rev Med Pharmacol Sci 2018; 22 (10): 3249-3260.

Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction. Vezzani B, Shaw I, Lesme H, Yong L, Khan N, Tremolada C and Péault B. Stem Cells Translational Medicine, Volume7, Issue12, 876-886.

Micro-fragmented adipose tissue for treatment of knee osteoarthritis with Baker’s cyst: a case study. Arthurs JR, Desmond CM, TerKonda SP and Shapiro SA. BMJ Case Rep. 2018; 2018: bcr2018224426.

See also -



eBook - The Magic of Fat Cells

A discussion by Professor Paul Lee about the changes one sees in osteoarthritis of the knee, and the role of regenerative medicine and surgery in improving the status of the joint cartilage in an effort to delay, or even prevent, knee replacement.