Autologous chondrocyte implantation (ACI) is a surgical procedure involving the injection of a person's own cultured joint cartilage cells back into a prepared defect in the cartilage.
The defect is cleaned up and then the chondrocytes are then injected behind a membrane that is sewn onto the defect
The two-stage procedure of ACI
This is known as a two-stage procedure, because the surgeon needs one procedure to harvest some healthy cartilage from a less important area and send the sample to a laboratory for culture (where they are multiplied and make many cells), and then there is a second procedure to implant the expanded cells into the damaged area to grow into healthy cartilage.
Professor Paul Lee discusses "ACi ten years on"
Orthopaedic and sports medicine specialist, Professor Paul Lee, discusses the way in which ACI has progressed over the last decade.
*Please note that this is a replay of a live event. Questions were asked and answered during the original event, but there is no live moderator during this replay.
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Cell-based tissue engineering strategies used in the clinical repair of articular cartilage. Huang BJ, Hu JC and Athanasiou KA. Biomaterials. 2016 Aug; 98: 1–22.