Pigmented villonodular synovitis (PVNS) is an unusual condition of the lining inside the knee joint, where the synovial cells are abnormal - proliferating into both villi (fronds) and nodules, laden with a brown pigment.

Pigmented villonodular synovitis low mag
Microscopic view of a piece of tissue showing the blobs of darker pigmentation between the pinker but overgrown synovial tissue.

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Cause/Cure of Recurrent PVNS***.

Synovectomy (partial or otherwise).

Recovery after a very extensive synovectomy of the knee


Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. Temponi EF, Guimarães Barros AA, Paganini VA, Barbosa VAK, Badet R and Lde Carvalho Júniora LH. Rev Bras Ortop. 2017 Jun-Jul; 52(4): 450–457.

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