I had 2 runs of SUpartz. The first was in 2005-only 3 shots approved and did virtually nothing. I tried them again in the early spring of 2008, as a last ditch effort to put off some kind of knee replacement. I had 5 shots which did nothing. I concluded my knee, by then, was too far down the road and had in fact, arrived at bone-on-bone arthritis. Shortly after that, I had a consultation about knee replacement and had a partial knee replacement in Sept. 2008. For me, the SUpartz did nothing--but I probably had it too late. I wold consider trying it sooner on my other knee which is also getting bad, but not as bad as the right one was in 2008. No idea if it's possible to measure how much is in there. It does help some people, even though it sure didn't do anything for me !