Arthrofibrosis Research Being Done Anywhere????

[Decruz]

Hi,
may I ask someone to help me in contacting the authors of the only relevant anti-fibrotic treatment without available e-mail addresses?

Article/research: Use of the class of synthetic antibiotics known as fluoroquinolones to effectively inhibit scar tissue formation or reduce preexisting scar tissue
Link: http://www.patentstorm.us/patents/6060474/description.html
Type: treatments on humans
Related authors: Riley J. Williams, Hannafin, Jo A.
Contact: (see related links below)
Related links: http://www.hss.edu/physicians_williams-riley.asp, http://www.hss.edu/physicians_hannafin-jo.asp
Location: Hospital for Special Surgery NY & Greenwich, CT

In the related links you can find the author pages in their clinics to call them, but beeing in Europe it would be an internbational call, some in US can call them?
I've e-mailed all the other authors of the other research/treatments and I'm waiting for their replies...
So, someone from US that will call Dr.Riley J. Williams and/or Dr.Hannafin, Jo A.?
Please give me a feedback - thank you

[missmyknee]

Here we go again

Note the doctor's level of expertise and interest

http://www.jefferson.edu/facint/details.cfm?key=taf103#

Here is a regimen of pain management done in the pre-op, during surgery, post-op and discharge, to prevent AF in a TKR It's very good except for the use of Darvon or Darvocet N 100 for discharge meds , which have been taken off the market, because of heart rhythm problems.  Please note the use of Celebrex

Multimodal Pain Management and Arthrofibrosis
http://docs.google.com/viewer?a=v&q=cache:Pl3o1E4L320J:www.orthomercy.com/wp-content/uploads/2010/08/Multimodal-Pain-Management-and-Arthrofibrosis.pdf+arthrofibrosis+research&hl=en&gl=us&pid=bl&srcid=ADGEEShBNfIT9FNPGYoGtG57vSUJDgZiNQAmrAoDSL26o7W2b6YYWn3KC5PWttxBd1QNb5X1fFsO16Wil-
T7zZBNY0RG1kasiGzSi7DhFiNqzxY_RWXg3m4Svp0LAtxRXu_-rsMYqYtG&sig=AHIEtbRI5vMBIYT93NQ_htOgMaL1jtaaVA

Here is a study on Celebrex and adhesions

Celebrex (Celecoxib) Appears to Prevent Adhesions After Surgery
http://www.pslgroup.com/dg/24995A.htm  

The first paragraph of the next article points out why it has been difficult to come up with a drug to combat arthrofibrosis. The article goes on to explain in detail why

http://www.novoseek.com/article/PMC/2805599/?query=arthrofibrosis

This article shows how a silicone membrane was used to prevent AF in the knee and it's failure

Failure of interpositional membrane to prevent recurrent arthrofibrosis.
http://www.biomedsearch.com/nih/Failure-interpositional-membrane-to-prevent/21329259.html

Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis.
http://www.biomedsearch.com/nih/Autologous-platelet-gel-fibrin-sealant/17323096.html

Below, read chapter 12 , page 126 thru to page 131. The last 2 paragraphs of pg 131 list all the methods being researched besides the Decorin and Hyaluronan

http://books.google.com/books?id=nxiCfmXPkzYC&pg=PA129&lpg=PA129&dq=anti-arthrofibrosis&source=bl&ots=jOdFJ_O64n&sig=gRFmBACGiC_m7W4XPWufPhQqIuk&hl=en&ei=rmhsTayeA5G4sAPwseC6BQ&sa=X&oi=book_result&ct=result&resnum=5&ved=0CCsQ6AEwBDgU#v=onepage&q&f=false

That's all for now

Pam

[Don Draper]

Hi. New member and fresh Arthrofibrosis diagnose too. Great forum ! Had 3 weeks ago a knee surgery(again) and after that the doctor mentioned
Arthrofibrosis. They did a manipulation(it was not a planned procedure) during the narcosis, extended the flexion range from 100-130 by force,
o boy the Quadriceps was sore after that....I did not get any specific instructions, jut the normal knee rehabilitation program.

After a couple of days, despite motion training, the stiffness started, flexion was less and less and pain was horrible.  I spent a lot of time on the web, "pubmed" and other sites to desperately find any insight in the issue. Based on my findings , hypoxia, reactive oxygen and associated oxidative stress seams to be connected to Arthrofibrosis. Inflammation should be avoided at any price.

Then tried to figure out in what way would reduce the things going on in my body without too big risk, to conduct a uncontrolled human study Concluded that Glutamine, R-Lipoic Acid and N-acetylcysteine might be beneficial, without much risk. So started to take high quality whey protein, D vitamine,  R-Lipoic Acid and N-acetylcysteine  supplements in addition to ice and inflammatory medication.

Would say it made a huge difference. Not so much to my cartilage damage pain in my patella but to the other soft tissue issues.  My ROM started to improve rapidly, can now use a stationary bike fairly well. Not yet at the 130 but close to 110 and improving. However dont expect any miracles as the patella has edema and the shape of the knee is changed compare to the first surgery one year ago. Before that had full ROM.

This might be a coincident or then not, however the progress of my knee is on a totally different level than it was on my first surgery. It seam like in my case it is the upper part of the knee that is  affected worst by arthrofibrosis, despite nothing has been done to those parts in either surgery. I have no medical education or encorage anyone to do the same, however wanted to share my own experience. And in my opinion there is also some scientific evidence that those supplements might have a beneficial effect on the conditions related to Arthrofibrosis. Direct studies with those supplements did not find.

[Don Draper]

Hi again.

In fact here a study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818240/ where N-acetylcysteine is studied related to Arthrofibrosis. As also glutathione levels. Intake of Glutamine(part of whey protein)increase glutathione levels. I start to think maybe this is not placebo after all......

Anyone else had any experience about these suplements, good or bad?

[Decruz]

2 feedbacks:

Article/research: Clinical Benefits of Intra-articular Anakinra for Arthrofibrosis
Link: http://www.orthosupersite.com/view.aspx?rid=77608 or http://orthopedics.researchtoday.net/archive/6/12/3121.htm
Related authors: Christopher A. Brown, MD; Alison P. Toth, MD; Bob Magnussen, MD
FEEDBACK: not indicated with previous infections

Article/research: Collagen Fibril Formation, A NEW TARGET TO LIMIT FIBROSIS
Link: http://ukpmc.ac.uk/articles/PMC2533774
Related authors: Li Hye Jin Chung, Andrzej Steplewski, Kee Yang Chung, Jouni Uitto and Andrzej Fertala
FEEDBACK: not available for patients, currently the method is at the experimental stage of development


That's it, at the moment

[Decruz]

Other feedback I've received (all the below listed articles/researches are conducted by the same researchers in Pittsburgh:



Article/research: Researchers cut fibrosis formation, increase muscle strength after injury - The Use of Suramin, an Antifibrotic Agent, to Improve Muscle Recovery After Strain Injury - Antifibrotic effects of suramin in injured skeletal muscle after laceration - Using decorin, an anti-fibrosis agent, to improve muscle recovery after injury - Muscle injuries and repair, current trends in research - The Use of Relaxin Improves Healing in Injured Muscle
Link: http://www.orthosupersite.com/view.aspx?rid=3885 - http://ajs.sagepub.com/content/33/1/43.abstract - http://jap.physiology.org/content/95/2/771.full - http://www.sportsinjurybulletin.com/archive/decorin.htm - http://www.thiagovilelalemos.com.br/downloads/musculo/Muscle%20injuries%20and%20repair.pdf - http://onlinelibrary.wiley.com/doi/10.1196/annals.1282.060/abstract
Type: biochemical AF process + possible treatments
Related authors: Li Y, Fu FH, Huard J
Location: University of Pittsburgh, USA
FEEDBACK: no trials available, just experimental studies

Bye

[missmyknee]

Found some more articles

This is an interesting article using milk from hyperimmunized cows called Microlactin

Technical Brief: Pharmacology of Microlactin™
http://docs.google.com/viewer?a=v&q=cache:khKamNLv4w0J:www.duralactin.com/pdfs/Duralactin%2520Pharmacology.pdf+controlling+adhesions+by+pharmacology&hl=en&gl=us&pid=bl&srcid=ADGEESjOCh-LsjX5vZ6yRbYliVoCkGpfW4JkgLEcdsbg8cnFLSP0GRZoBsoYgqujk2_0kv-BiYAwTCIQ51ZrUYDza9Li716IxW5WIm7KewBNfQivx_JzVGe6C85QX3l_8gL9jPHB0sra&sig=AHIEtbQ8p2_0hjAUE4oGy43LSZARgd6xBA

Adhesions: preventive strategies

Adhesions: preventive strategies.
http://www.ncbi.nlm.nih.gov/pubmed/9076450

SyntheMed
http://www.onemedplace.com/database/list/cid/595/

The Use of Osteopontin

Skin Care: Scar-Free Healing Shown With Gene Suppression
http://www.sciencedaily.com/releases/2008/01/080121080355.htm

Mechanism that limits scar formation discovered

Mechanism That Limits Scar Formation Discovered
http://www.sciencedaily.com/releases/2010/06/100610154459.htm

Would not want this type of scarring

Mechanism That Limits Scar Formation Discovered
http://www.sciencedaily.com/releases/2008/01/080129170711.htm

Tenascin-C

Molecular Muscle: Small Parts of a Big Protein Play Key Roles in Building Tissues
http://www.sciencedaily.com/releases/2011/03/110323140152.htm

Sugar molecule

Molecular Muscle: Small Parts of a Big Protein Play Key Roles in Building Tissues
http://www.sciencedaily.com/releases/2010/12/101212121734.htm

Adhesion Prevention: state of the art

Adhesion prevention: state of the art
http://docs.google.com/viewer?a=v&q=cache:4p_iokMI7o0J:www.ceverj.com.br/conteudo/publucacoes/video_histeroscopia/03.pdf+preventing+adhesions+by+pharmacology&hl=en&gl=us&pid=bl&srcid=ADGEESiJhFq3Rbqm7MWUBESrbmlVaRNnSN9k7a32QYVB18LiJDWnnRgJ5p_taHqrM_8y_zK9oEgJzjxX0wrevUVBtBPUplCLKIn2TckkhVqyya4AhSbkpZxIjEyISTLnpHHqIwImkBr8&sig=AHIEtbQiLq5gqyiFZGk1TCBgqYMLE4kr0w

Novel Product for the Prevention of Post-Surgical Adhesion Formation Completes Phase I Clinical Study

Novel Product for the Prevention of Post-Surgical Adhesion Formation Completes Phase I Clinical Study
Source: redOrbit (http://s.tt/17mCU)
http://www.redorbit.com/news/health/1720336/novel_product_for_the_prevention_of_postsurgical_adhesion_formation_completes/index.html

The Effect of Tenoxicam on Intraperitoneal Adhesions and
Prostaglandin E2 Levels in Mice


The Effect of Tenoxicam on Intraperitoneal Adhesions and Prostaglandin E2 Levels in Mice
http://www.anesthesia-analgesia.org/content/88/4/939.short

Adhesion Reduction Options


http://docs.google.com/viewer?a=v&q=cache:dOt2_sc1-poJ:www.touchbriefings.com/pdf/1816/ACF427D.pdf+preventing+adhesions+by+pharmacology&hl=en&gl=us&pid=bl&srcid=ADGEESj_ojxXa4y84viPmI-h1wciQpbiB7rYo3VjUn0RlfIPxanXQs7vncJPZwINl5Zi2f_URwUn81DPZ2pq7ku9hySbGHjN1O2jMWJTezC4k7GidmzA7Kfoxw4XvKCIyuNNxMgdxHFk&sig=AHIEtbRmuiw6zUMplMFpMFS77zbe7sXQLQ

Invention To Prevent Surgical Adhesions Wins Kaye Award
http://www.medicalnewstoday.com/articles/111351.php

Adhesions: pathogenesis and prevention-panel discussion and summary
http://www.ncbi.nlm.nih.gov/pubmed/9076453

Chymase inhibitor in inflamed tissue remodeling and fibrosis
http://www.ncbi.nlm.nih.gov/pubmed/12499572

Development from Preglem
http://docs.google.com/viewer?a=v&q=cache:aFQS2udon2MJ:www.preglem.com/files/newspdf/PR_JNKI%2520July%25202010%2520FINAL_ENGLISH_kp%2520_3_.pdf+preventing+adhesions+by+pharmacology&hl=en&gl=us&pid=bl&srcid=ADGEESjM_Cqq0RJNgNIRy3QTpw1vVDPkYYOFF1zSNfVBsIk5acubHymj84bgrGu5xHc0_u_J3qoNx9O_AMSLA7Tvv8KohcN2QVnNtvENRJGr3hCwOc4fSPorMp0Jbj1LoYSl6cOTOSbs&sig=AHIEtbQ_Q34iYKOG15ovGMJGolP6cD_4Xw

Kytogenics Pharmaceuticals Inc Medical Devices
http://www.kytogenics.com/medical_devices.htm


I realize some of these articles are about adhesions in other areas of the body, however no matter where they occur, it is painful,out-of-control, and debilitating like it is in the knee. If a discovery is made for one fibrotic area or condition, the hope would be, that it might work for our nitch in the adhesion world, arthrofibrosis.

That's all for now

Pam

[Don Draper]

My Human study continues. Glutamine, R-Lipoic Acid and N-acetylcysteine is what i take, changed the whey proteine to pure glutamine. This week i was for the first time able to grab my ankle in 1,5 years, the knee is flexing much better than before, maybe 140 degrees. And I have not been doing very much streching.  In my case the work need to be done on the cell level, training alone will not cure it.  My Joint condition is still bad and painfull buy very happy to slowely recover the ROM, at least partly.

I think the study i posted previously is worth reading.

[Decruz]

My Human study continues. Glutamine, R-Lipoic Acid and N-acetylcysteine is what i take, changed the whey proteine to pure glutamine. This week i was for the first time able to grab my ankle in 1,5 years, the knee is flexing much better than before, maybe 140 degrees. And I have not been doing very much streching.  In my case the work need to be done on the cell level, training alone will not cure it.  My Joint condition is still bad and painfull buy very happy to slowely recover the ROM, at least partly.

May you please post what dosage you're taking of all of them? I guess the recommended one reported on the label...

By the way, I found sources reporting radiation used as anti-fibrotic treatments - just the report about this too.

[missmyknee]

Hi

There was some discussion using radiation for arthrofibrosis a couple years ago between former posters

http://www.kneeguru.co.uk/KNEEtalk/index.php?action=search2

Pam

[bumkneeblonde]

To all who posted articles and info, THANK YOU SO MUCH! We need to find a cure for AF, we NEED to!!!

[Decruz]

Hi,
another feedback from Mexico about Pirfenidone: they don't have PFD in oral formulation to treat other disorders than hepatic fibrosis (experimental stage), but I was suggested to at least try Pirfenidone in the form of 8% gel (used to topically treat keloids/hiperthrophic scars) that after my researches seems to be only sold in Mexico under the name "Kitoscell".
One of you in US can please check if is already sold in US under maybe a different name (not available in the EU countries I've checked)?
THANK YOU

[missmyknee]

Hi

A lot of times the U.S. FDA, is behind the E.U when it comes to approving the use of a drug.

Pam

[Decruz]

Hi

A lot of times the U.S. FDA, is behind the E.U when it comes to approving the use of a drug.

Pam

Hi Pam,
is this a general consideration or have you checked into a pharmacy finding out the gel isn't available even under another name?
Thank you

[Decruz]

Hi,
may I ask someone to help me in contacting the authors of the only relevant anti-fibrotic treatment without available e-mail addresses?

Article/research: Use of the class of synthetic antibiotics known as fluoroquinolones to effectively inhibit scar tissue formation or reduce preexisting scar tissue
Link: http://www.patentstorm.us/patents/6060474/description.html
Type: treatments on humans
Related authors: Riley J. Williams, Hannafin, Jo A.
Contact: (see related links below)
Related links: http://www.hss.edu/physicians_williams-riley.asp, http://www.hss.edu/physicians_hannafin-jo.asp
Location: Hospital for Special Surgery NY & Greenwich, CT

I've e-mailed all the other authors of the other research/treatments and I'm waiting for their replies...
So, someone from US that will call Dr.Riley J. Williams and/or Dr.Hannafin, Jo A.?
Please give me a feedback - thank you

Feedback received: although the patent for the concept was filed it has not been used and there has been no clinical work documenting that it is helpful in a condition such as arthrofibrosis.

Goodbye