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Author Topic: Regenexx injections - Stem Cells  (Read 223752 times)

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Offline blindy

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Re: Regenexx injections - Stem Cells
« Reply #150 on: May 24, 2009, 06:11:46 PM »
I see valid points from both sides--those who realize that the FDA is here to protect us from quackery and those who have been given hope that Dr. Cetano may provide a solution for lifelong suffering.

One of the problems I have with the FDA is that a number of drug company executives have sat on its board and I can't believe they are objective. I look at drugs like Crestor that lowers cholesterol yet had subjected 29 people to deadly rhabdomyolysis in the pre-trial clinical studies. How many drugs pass FDA scrutiny for political reasons? I'm sure the balance of the FDA's work is good yet I look at how medical invention evolves and have to think of Ignatz Semmelweis, the founder of germ theory, who was put into a mental institution where he later died for bucking the conventional views of medicine. 80 years later, he was discovered to be correct. A lot of good that did Ignatz and so many people he might have saved from harrowing disease.

On the other hand, I do understand that we need standards and good points were made here about any Tom, Dick and Harry setting up a clinic without guidelines and killing people. It's a dilemma but I'm looking at the body of work that Dr. Centano has done and have yet to hear of a patient who has complained about his clinic. Isn't it people like Dr. Centano who create lifesaving breakthroughs because they have the guts to fight for a cause? Of those 250 patients who have experienced his procedure, I would think any disgruntled patients would have used this forum to speak their mind. I haven't seen that. I have seen people give him rave reviews.

Let me tell you my story. I had county track records for the 440 in high school. I used to run like the wind when I was 17 and almost felt as though I was flying. What a rush! Then I went out for a pass, made an extreme cut and tore my medial meniscus. In the 1960's they didn't have arthroscopes and had to go into the knee capsule. My recovery was slow and I could never run well again. I have had 7 knee surgeries (debridements, removing bone chips and two high tibial osteotomies (the first was a failure and caused foot palsy for a year; in fact the leg was not angled properly and the whole thing had to be done over). I, like many of you, have suffered arthritic pain my whole life, have given up sports that I love because I simply couldn't perform any more. After a while, you learn to try to put all this in the background but it is always there in its haunting unconscious way and when the knee acts up and causes two weeks of disability at a time, I try to suck it up and move on.

Two years ago, I discovered that both my hips were shot. I researched everywhere to find a solution. I contacted Dr. Centano and sent in my mri's. They were honest. My hips were so out of round that even if new cartilage was formed, it would be worn down. They were honest about that and didn't look to sell me a bill of goods.

I am now 6 months recovered from bi-lateral hip replacement and still have pain in my left femur when I walk and lingering pain on my right side when I sleep that shoots into my knee. My surgeon was excellent and has done 14,000 hips but surgery is not a perfect science and hopefully, I'll fully recover.

That brings me to my knee. I am a vital person who loves life. As many of you, that has been compromised for decades by this painful and debilitating knee. From being a star athlete to a semi disabled person, the transition is tough and doesn't end. I have a great business that is now starting to take off and I will be able to work whenever I want and the money will keep growing. All that becomes meaningless if I can't dance, play golf, and be my active self.

So I ask, if Dr. Centano's procedure doesn't bring me to the promised land and even if it has some question marks, who else is offering me hope? I have communicated with his office and have found my experience with them to be very positive. My business is based upon building trust and positive relationships. With Dr. Centano, I see a man who may or may not be working within the system, but what I have experienced in my due diligence is a feeling of trust towards him and his people. I don't want the government to take that one hope away from me.

And what if it does work? And what if he actually can get me back to a normal life and do so for others? I doubt anyone on this forum is here without suffering horrendous, life limiting challenges because of his or her knee issues. I see someone who is challenging the status quo and people are benefiting on an incredible level.  I am 63. If I have to have a total knee and suffer a possible revision sometime in my 80's that's not something I want to think about but I'll do this if nothing else can work. With that as an alternative and all the suffering from recuperation, Dr. Centano's procedure seems not only appealing but the most rational choice.

It is easy for us to criticize and judge without personally knowing the man. It is always harder to assume that some people might really be iconoclastic but honorable nonetheless. We look at our politicians, the banking establishment, the oil companies and at cable news (which is all about ratings and has nothing to do with news) and we get jaded;  we believe that everyone has a secret agenda and is ready to rip us off. I believe that in the midst of this, there are a class of honorable people, striving to do good. Until I see otherwise, I believe Dr. Centano is one of them.

Blindy

Offline Saverio

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Re: Regenexx injections - Stem Cells
« Reply #151 on: May 25, 2009, 02:08:52 PM »
Hi All,

If you read this sections posts you would know I am a 2 time recepient of Dr. Centeno's regenexx procedure (once in each knee).  I am doing great and am planning to go back for another procedure in my right knee.  I wanted to take this time to inform you of 2 prominent Orthopedic clinics that are using or looking into Stem Cells.  One is the Stone Clinic (http://www.stoneclinic.com/stemcells).  Dr Stone did do a microfracture on my left knee and I scheduled with him bi-lateral TKRs before I found regenexx.  The other is Steadman-Hawkins (http://www.shsmf.org/).  They also are world reknowned.    I do believe stem cells is the future of cartliage restoration.

Saverio

Offline mccartjt

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Re: Regenexx injections - Stem Cells
« Reply #152 on: May 29, 2009, 02:34:38 AM »
Saverio

I think the genie is soon going be out of the box. NEOSTEM  see stock price here  http://finance.yahoo.com/q?s=NBS

& press release here...

http://finance.yahoo.com/news/NeoStem-Obtains-Exclusive-prnews-15197487.html?.v=1

JM

Offline 60schld

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Re: Regenexx injections - Stem Cells
« Reply #153 on: May 29, 2009, 03:40:12 AM »
Saverio,  Since you were one of the first on this forum to post your experience, do you think this procedure is going to be a permanent fix, or will we need to redo it every so often?  Thanks, 60schld
TKR  finally done!!!  9/9/13     Whew!!

Offline Saverio

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Re: Regenexx injections - Stem Cells
« Reply #154 on: May 29, 2009, 01:16:05 PM »
I've only had 2 procedures and can only speak on my experience.   I have noticed improvement in level of pain (discomfort) and mobility after each procedure.  Are my knees back to where I want them?  No.  But there is marked improvement.  Given that I only have about 10% of my lateral meniscus in each knee, doing nothing I believe wear and tear will break down any improvement over time.  My hope is that as I receive more procedures the technology will advance to a level where the improvement is greater.  This is still better than any microfracture I have done.   And defintley a better alternative than TKR.

Offline mccartjt

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Re: Regenexx injections - Stem Cells
« Reply #155 on: May 30, 2009, 03:13:45 AM »
Saverio

Do you know how many stem cells you've had injected into each knee so far? I've have had a total of 75million on my left knee..

Offline Saverio

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Re: Regenexx injections - Stem Cells
« Reply #156 on: May 30, 2009, 12:49:45 PM »
Left knee = 25 mil,   Right knee =  29 mil

Offline slyguy1

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Re: Regenexx injections - Stem Cells
« Reply #157 on: June 01, 2009, 06:32:08 PM »
Would anyone have any comparative success of this versus ACI procedures. I understand ACI is very invasive open surgery and very long recovery but on a longterm basis is ACI more permanent than stem cell proc? Any websites with meaningful info on this?

Offline NikkiE

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Re: Regenexx injections - Stem Cells
« Reply #158 on: June 02, 2009, 01:48:32 AM »
Left knee = 25 mil,   Right knee =  29 mil

That's a little cryptic!

Is this how much cartilage has been regenerated>?
Chondromalacia in right knee for 13 years. 

OA in medial section of right knee, almost bone on bone.

OA in medial section of left knee

Offline Saverio

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Re: Regenexx injections - Stem Cells
« Reply #159 on: June 02, 2009, 12:51:14 PM »
Nikkie,

It simply means Dr.  Centeno injected 25 million stem cells in my left knee and 29 million in my right knee.

Offline mccartjt

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Re: Regenexx injections - Stem Cells
« Reply #160 on: June 02, 2009, 04:24:56 PM »
Slyguy1

I am sure that in time that info you are looking for will be available. The Osiris  Chondrogen procedure was with either a low dose 50 million or a high dose 150 million stem cells, (read more here.. http://investor.osiris.com/releasedetail.cfm?ReleaseID=278696 )  I've had half that number. Osiris patients have had some success. Although those stem cells were 'supposedly allogenic' not autologous. There's a big issue for me at least with allogenic v. autologus.

Sly to your point of ACI very invasive, yup you are correct on that one. 12 months rehab plus the chance of overgrowth too with an additional arthroscopy needed also. When you 50+ years of age, a 12 month rehab akin to what an NBA basketball player would have to endure is frankly a bit too excessive unless you are basketballer! I want to grow old 'Gracefully' I don't have time to live at the gym..

That NeoStem has licensed the Regenexx procedure for (essentially China) Asia I am sure over time there will be more clinical evidence coming out.

Offline slyguy1

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Re: Regenexx injections - Stem Cells
« Reply #161 on: June 03, 2009, 03:30:42 PM »
Hi mccartjt......being an active person most of my life i don't mine spending time in the gym but i am definitely not interested in competitive sports just keeping fit and holding onto what i have is my personal goal. So what is the issue of allogenic vs autologus? I am thinking that the most successful candidates are the ones with minor lesions that have not been compromised by any other surgical procedure such as microfraction which is what i had done. I think i posed this question a while back but had no clear cut answer. My microfraction has run its course and i have been holding off as much as possible for such a procedure but i don't know if it will help me....most os out there laugh at the idea....thanks for your imput

Sly

Offline mccartjt

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Re: Regenexx injections - Stem Cells
« Reply #162 on: June 03, 2009, 06:24:24 PM »
Slyguy1

Autologous means cells that originally come from you. Allogenic are donored cells that can come from anyone. ~ You are unsure of their lineage, thus unsure if the donor had undiscovered AIDS or other ailments etc.. The Regenexx procedure for generating stem cells to regrow your cartilage, come from your own bone marrow, so theoretically no chance of contamination. (There is always some risk in any procedure). Osirsis did their phase II/III study on a drug called Chrondrogen which is allogenic (this is almost identical to Regenexx). Osirsis in this situation represents "Big Pharma".

I will digress here, one "Big Pharma company" markets "Lamisil" for toe nail fungus. The three month treatment plan costs $1000.00 for the tablets.  My insurance company wouldn't pay for the treatment & I have a good PPO medical plan. I went to see a skin specialist doctor  and he told me a $10.00 jar of Vics Vapor rub will cure toe nail fungus. What do you know 3 months later my toe nail fungus is gone & no $1000.00 course of Lamisil.  So much for big pharma. Big pharma is looking out for themselves.

This is probably the heart of the matter with Regenexx and FDA. The FDA 's approval process is skewed towards big pharma = expensive money making procedures to fatten Pfizer/Merck/GlaxoSmithKline's profits. With Regenexx the procedure for 1 set of 3 injections is about $7000.00. I have a friend that has had a double total knee replacements. So far his surgery (without all the physio) bill has come in at $100,000+. The pain was 9.5 against 10 for two weeks post surgery & then loads of rehab. His course with Regenexx might have cost him about $16-20,000.00 & a lot less pain.

Sly

As for your condition, I'd get in touch with Regenexx and see what they can do for you..

Good luck!

JM

Offline slyguy1

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Re: Regenexx injections - Stem Cells
« Reply #163 on: June 05, 2009, 03:53:11 PM »
.......on the lamisil i believe there is a generic version that your insurance will pay for in case if you ever need it again.....but hey if vicks works for you great:) As far as cost goes i believe the ACI procedure is about the same (100,000+) and if you can grow the same cartlige with half the recovery time....it is just too good to be true is what my gut feeling says....have a good one:)

Offline mccartjt

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Re: Regenexx injections - Stem Cells
« Reply #164 on: June 06, 2009, 04:49:54 AM »
Sly

Yup the Vicks Vapo rub worked well. As for the recovery time, cartilage takes time to grow. You can't cheat the growing time needed. The recovery post ACI is extremely difficult, your muscles atrophy etc, that's not the case with Regenexx.

Lets get this clear, Regenexx so far hasn't given me perfection, but my knee is much better. Do I  believe in the procedure? Well I am scheduled back at their clinic for another procedure in 2 weeks. & I am paying..  JM