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Author Topic: Glucosamine/chondroitin - what is best dose?  (Read 3377 times)

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Offline shiphen

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Glucosamine/chondroitin - what is best dose?
« on: March 19, 2003, 02:15:19 PM »
From what I read
1) Glucosamine HCL is better than Glucosamine Sulphate,
2) MSM does not good
3) Chondriotin Sulphate is more effective than *just* Glucosamine
    but the best thing is to take both at once!

But what is the best *dose*?!
[I am 42, male, in broadly good health,  about 12 stones in weight - c168 lbs]

1200 mg of Chondrioitin...?

Ship

Offline Janet

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #1 on: March 19, 2003, 04:13:43 PM »
I recently read a journal article about glucosamine, but can't find it now. However, try this link. It is a consumer's guide to glucosamine and has tons of information.

www.arthritis-glucosamine.net/glucosamine

Janet

« Last Edit: March 19, 2003, 04:16:34 PM by Janet »
Torn quad tendon repair & VMO advancement 4/99, MUA with LOA 10/99, Patella baja and arthrofibrosis, LR & medial release & LOA 5/01, LOA & chondroplasty 6/03,TKR on 11/06, MUA 12/06. From perfect knees to a TKR in 7 years, all from a fall on a wet floor...and early undiagnosed scar tissue.

Offline shiphen

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #2 on: March 20, 2003, 01:59:56 PM »

That website:
www.arthritis-glucosamine.net/glucosamine
seems heavily biased towards glucosamine rather than
Chondriotin.

Also it may be out of date because it claims that

"...there is no proof that either substance, taken singly or in combination, will actually slow the degenerative process or restore cartilage in arthritic joints."

I regard this site as extremely amateur and ham-fisted because it is not dating its articles. Nor giving proper scientific references.

I am not impressed.

Can anyone suggest any better source of info?!

Ship
Shiperton Henethe







Offline Janet

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #3 on: March 20, 2003, 11:17:09 PM »
Sorry. I hoped it might have some info you'd find helpful. I'll keep looking for the other article. It was in one of the recent ortho journals and said that glucosamine really did help. I just don't remember the dosage they recommended.

Janet
Torn quad tendon repair & VMO advancement 4/99, MUA with LOA 10/99, Patella baja and arthrofibrosis, LR & medial release & LOA 5/01, LOA & chondroplasty 6/03,TKR on 11/06, MUA 12/06. From perfect knees to a TKR in 7 years, all from a fall on a wet floor...and early undiagnosed scar tissue.

Offline Janet

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LiRe: Glucosamine/chondroitin - what is best dose?
« Reply #4 on: March 21, 2003, 10:00:40 PM »
Here is the link to the article. It was unde the literature review section of the ortho section in Medscape. You have to scroll to the last page to find the article on Glucosamine. You'll see the study used 1500 mg/day of glocosamine sulfate.

www.medscape.com/viewarticle/449417

Janet
Torn quad tendon repair & VMO advancement 4/99, MUA with LOA 10/99, Patella baja and arthrofibrosis, LR & medial release & LOA 5/01, LOA & chondroplasty 6/03,TKR on 11/06, MUA 12/06. From perfect knees to a TKR in 7 years, all from a fall on a wet floor...and early undiagnosed scar tissue.

Offline The KNEEguru

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #5 on: March 22, 2003, 08:57:33 AM »
My computer locks up when I try this second link.
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Offline ATsoccergirl

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #7 on: March 25, 2003, 04:59:05 AM »
Glucosamine/Chondroitin is containdicated after ACL surgery (or any other reconstructive surgery).  It has been shown to greatly increase scar tissue and the risks of arthrofibrosis.  
1999 LR, 2002 ACL/PLC recon, reversal of LR, 2004 ACL revision, 2006 Car accident torn PCL and small fractures resulting in bone chips in my knee.  Torn MCL 3 times.  Wicked screws under IT band and Pes Anserine.  June 2008-Hip Arthroscopy.

Offline Heather M.

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #8 on: March 25, 2003, 06:01:50 AM »
Could you please tell us where you found this information?  Any studies published on this issue?  I've had tons of arthrofibrosis, but not while taking glucosamine.  It's always been recommended to me....

Heather

Scope #1: LR, part. menisectomy w/cyst, chondroplasty
#2-#5: Lysis of adhesions/scar tissue, AIR, patellar tendon debridement, infections, MUA, insufflation
#6: IT band release / Z-Plasty, synovectomy, LOA/AIR, chondroplasty
2006 Arthrofibrosis, patella baja
http://www.flickr.com/photos/hmaxwell

Offline Janet

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #9 on: March 26, 2003, 06:10:50 PM »
Sorry about that link. It worked when I tested it. Here is the text.

Janet


Glucosamine Delays Progression of Knee Osteoarthritis
Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo- controlled, double-blind study. Arch Intern Med. 2002;162:2113-2123.

Long-term treatment with glucosamine sulfate may retard progression of knee osteoarthritis, according to the results of a three-year, randomized, placebo-controlled, double-blind study published in the Archives of Internal Medicine. Glucosamine sulfate is a pharmaceutical derivative of the naturally occurring aminomonosaccharide.

Participating in the study were 202 patients with long-standing (> 10 years) and mild to moderate severity knee osteoarthritis. Baseline visits included a physical examination, a knee radiograph, and a questionnaire that assessed patients' symptoms using the Lequesne index and the WOMAC (Western Ontario and McMaster universities) index with certain subscales. Patients were excluded if they had a history of clinically significant articular and rheumatic diseases other than osteoarthritis or if they were overweight (defined as a body mass index > 27).

Patients were randomized to receive either 1,500-mg/d of glucosamine sulfate (single dose) or placebo. Symptom assessments were performed quarterly, and a knee radiograph was taken at the end of each year. Changes in radiographic minimum joint space width were measured in the medial compartment of the tibiofemoral joint.

The average joint space width at enrollment was slightly less than 4 mm. After three years, placebo patients experienced average joint space narrowing of 0.19 mm, while space narrowing among users of glucosamine sulfate was negligible (0.04 mm). Compared with patients in the placebo group, fewer patients treated with glucosamine sulfate experienced substantial joint space loss (14% and 5%, respectively).

Also, patients in the placebo group experienced modestly improved symptoms, while those in the glucosamine sulfate group experienced as much as 20% to 25% improvement. There were also significant final differences between the two groups on the Lequesne index, the WOMAC total index, and pain, function, and stiffness subscales.

"[G]lucosamine sulfate is the first pharmacologic intervention that retards the progression of osteoarthritis during long-term treatment, according to the current scientific and regulatory recommendations," write the authors. "The compound merits further attention as a possible disease-modifying agent for the treatment of osteoarthritis."

Long-term use of glucosamine sulfate improves symptoms and slows progression of knee osteoarthritis.



Clinician Reviews 13(1):23-24, 27-30, 2003. © 2003 Clinicians Group, LLC

Torn quad tendon repair & VMO advancement 4/99, MUA with LOA 10/99, Patella baja and arthrofibrosis, LR & medial release & LOA 5/01, LOA & chondroplasty 6/03,TKR on 11/06, MUA 12/06. From perfect knees to a TKR in 7 years, all from a fall on a wet floor...and early undiagnosed scar tissue.

Offline ATsoccergirl

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Re: Glucosamine/chondroitin - what is best dose?
« Reply #10 on: April 02, 2003, 09:27:10 PM »
There are some studies out there.  I came across a really excellent study a while ago.  I forgot to save it  :'( and haven't been able to find it since.  My uncle is a knee specialist and is on the American orthopedic certification board.  He always advised me aganst taking it due to increased risk of arthrofibrosis.  He has done studies himself that have proven it.  
1999 LR, 2002 ACL/PLC recon, reversal of LR, 2004 ACL revision, 2006 Car accident torn PCL and small fractures resulting in bone chips in my knee.  Torn MCL 3 times.  Wicked screws under IT band and Pes Anserine.  June 2008-Hip Arthroscopy.