A selection of published medical articles (most recent first) about Arthritis and Joint Cartilage damage.

Because our team are always combing the medical literature for their editorial work, we thought it might be useful to others to see what we have been reading, and have put a link to the abstract available on PubMed. Where possible, we have located a copy of the full article and added a link, but your local library will also be able to obtain a reprint for you.

Regeneration of degenerated articular cartilage in the medial compartment can be expected while correcting a varus deformity in arthritic knees after medial open-wedge HTO with a locked plate system without any additional cartilage regeneration procedures.

Change of Chondral Lesions and Predictive Factors After Medial Open-Wedge High Tibial Osteotomy With a Locked Plate System. Kim KI, Seo MC, Song SJ, Bae DK, Kim DH, Lee SH. Am J Sports Med. 2017 Jun;45(7):1615-1621. doi: 10.1177/0363546517694864. Epub 2017 Mar 14.

Cartilage regeneration in degenerated articular cartilage is induced after opening-wedge valgus HTO, which is affected by BMI, the difference between the MFC and MTC, preoperative cartilage degeneration grade, and postoperative limb alignment. Therefore, patient selection by BMI rather than age, and surgical techniques maintaining valgus knee alignment should be considered for cartilage regeneration.

Factors affecting cartilage repair after medial opening-wedge high tibial osteotomy. Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y, Koshino T, Saito T. Knee Surg Sports Traumatol Arthrosc. 2017 Mar;25(3):779-784. doi: 10.1007/s00167-016-4096-z. Epub 2016 Mar 31.

Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms.

Hoffa's fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators.

Hoffa's Fat Pad Abnormality in the Development of Knee Osteoarthritis. Paduszyński W, Jeśkiewicz M, Uchański P, Gackowski S, Radkowski M, Demkow U. Adv Exp Med Biol. 2017 Aug 3. doi: 10.1007/5584_2017_77. [Epub ahead of print]

The infrapatellar fat pad (IPFP), the local fat around the knee joint, may play an important role in the initiation and progression of knee OA [7, 8].

Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study. Han W, Aitken 1, Zhu Z, Halliday A, Wang X, Antony B, Cicuttini F, Jones G, Ding C. Arthritis Res Ther. 2016 Oct 12;18(1):234. [Link to free full text article]