Prolotherapy is the injection of an irritant, usually dextrose, into disturbed soft tissues such as tendons and fascia in an effort to stimulate self regeneration with new cells.
It is postulated that the micro trauma caused by the dextrose results in local cell death, resulting in the release of a chemical cascade that triggers tissue regeneration.
Effectiveness and safety of prolotherapy injections for management of lower limb tendinopathy and fasciopathy: a systematic review. Sanderson LM and Bryant A. J Foot Ankle Res. 2015; 8: 57.
A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain. Hauser RA, Lackner JB, Steilen-Matias D and Harris DK. Clin Med Insights Arthritis Musculoskelet Disord. 2016; 9: 139–159.