Matrix-induced autologous chondrocyte implantation - or MACI - is a technique of cartilage repair involving growing cells on a matrix.

chondrocyte harvest
A tiny bit of healthy cartilage is harvested from a non-weight-bearing part of the joint, and sent for culture.

 

Technique of MACI

The technique uses the patient's own cells, which are multiplied in a laboratory, 'seeded' onto a membrane and shipped back to the surgeon for the second stage of the process when the membrane is implanted into the defect in the knee.

 

Synonyms: 
MACI
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Surgical cartilage repair for knee osteoarthritis

An overview of the various options available for surgical cartilage repair of the knee.

A simple flowchart with links to show the possible interventions in cases of knee arthritis.

This is the editor's 'interpretation' of a 2011 publication in the medical journals that gives an overview of cartilage injury, a brief description of current treatment options and outcomes, and a discussion of principles and techniques of MACI.

Biologic Knee Replacement

A course by knee surgeon, Dr Kevin R Stone M.D. of the Stone Clinic in San Francisco, California, USA.

Articular cartilage repair

A short but sound overview of the issue of damage to the joint cartilage, and what can be done about it.

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FORUM DISCUSSIONS

MACI Update - 11yrs and still going strong!

MACI Recovery

My MACI experience


CLINICAL PUBLICATIONS

Matrix-induced autologous chondrocyte implantation (MACI) in the knee. Enea D, Cecconi S, Busilacchi A, Manzotti S, Gesuita R and Gigante A. Knee Surg Sports Traumatol Arthrosc. 2012 May;20(5):862-9. doi: 10.1007/s00167-011-1639-1. Epub 2011 Aug 12.


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