Matrix-induced autologous chondrocyte implantation - or MACI - is a technique of cartilage repair involving growing cells on a matrix.

chondrocyte harvest
A tiny bit of healthy cartilage is harvested from a non-weight-bearing part of the joint, and sent for culture.


Technique of MACI

The technique uses the patient's own cells, which are multiplied in a laboratory, 'seeded' onto a membrane and shipped back to the surgeon for the second stage of the process when the membrane is implanted into the defect in the knee.



Surgical cartilage repair for knee osteoarthritis

An overview of the various options available for surgical cartilage repair of the knee.

A simple flowchart with links to show the possible interventions in cases of knee arthritis.

This is the editor's 'interpretation' of a 2011 publication in the medical journals that gives an overview of cartilage injury, a brief description of current treatment options and outcomes, and a discussion of principles and techniques of MACI.

Biologic Knee Replacement

A course by knee surgeon, Dr Kevin R Stone M.D. of the Stone Clinic in San Francisco, California, USA.

Articular cartilage repair

A short but sound overview of the issue of damage to the joint cartilage, and what can be done about it.



MACI Update - 11yrs and still going strong!

MACI Recovery

My MACI experience


Matrix-induced autologous chondrocyte implantation (MACI) in the knee. Enea D, Cecconi S, Busilacchi A, Manzotti S, Gesuita R and Gigante A. Knee Surg Sports Traumatol Arthrosc. 2012 May;20(5):862-9. doi: 10.1007/s00167-011-1639-1. Epub 2011 Aug 12.

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