Compartment overload is when too much stress is occurring within one of the three compartments of the knee.

The dotted lines are just there for illustration of how the three compartments take different stresses.
Stressing one compartment
If one of the compartments is overloaded - for example the medial tibiofemoral compartment, the lateral tibiofemoral compartment or the patellofemoral compartment - arthritis may develop in the area of stress.
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CLINICAL PUBLICATIONS
Clinical features of symptomatic patellofemoral joint osteoarthritis. Peat G, Duncan RC, Wood LRJ, Thomas E and Muller S. Arthritis Res Ther. 2012; 14(2): R63.
How Tibiofemoral Alignment and Contact Locations Affect Predictions of Medial and Lateral Tibiofemoral Contact Forces. Lerner ZF, DeMers MS, Delp SL and Browning RC. J Biomech. 2015 Feb 26; 48(4): 644–650.