Compartment overload is when too much stress is occurring within one of the three compartments of the knee.
Stressing one compartment
If one of the compartments is overloaded - for example the medial tibiofemoral compartment, the lateral tibiofemoral compartment or the patellofemoral compartment - arthritis may develop in the area of stress.
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Clinical features of symptomatic patellofemoral joint osteoarthritis. Peat G, Duncan RC, Wood LRJ, Thomas E and Muller S. Arthritis Res Ther. 2012; 14(2): R63.
How Tibiofemoral Alignment and Contact Locations Affect Predictions of Medial and Lateral Tibiofemoral Contact Forces. Lerner ZF, DeMers MS, Delp SL and Browning RC. J Biomech. 2015 Feb 26; 48(4): 644–650.