Characterised Chondrocyte Implantation (CCI) is a procedure to grow cartilage cells (chondrocytes), seed them onto a collagen membrane, and sew that membrane back onto the knee to cover a cartilage lesion.


Five year outcome

A study by senior researchers compared CCI to microfracture, and found that after five years the results were better than microfracture, but in the early stages the results were directly comparabe.


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Cost Effectiveness of Characterised Chondrocyte Implantation for Treatment of Cartilage Defects of the Knee in the UK. Elvidge J, Bullement A and Hatswell AJ. Pharmacoeconomics. 2016 Nov;34(11):1145-1159.

Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J and Luyten FP. Am J Sports Med. 2011 Dec;39(12):2566-74. doi: 10.1177/0363546511422220. Epub 2011 Sep 9.

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