Just read this thread through and thought I chime in with my limited understanding from own research. I was told by two MSC treatment providers to expect regeneration up to 1 year possibly 1.5 years. But dependent on the provider, the total number of cells injected varied. So for me, if the number of stems injected was relatively low, something like 50 million, that more injections are necessary and this raised the cost of course. From Dr. Centeno's website and data he has provided, seems the imagery of regeneration of cartilage have all been via MRI, as MRI probably provides a lot more details than X-ray. The concerns that you have post-procedure were bullet point question marks in my own research notes. I took a very un-bias approach to evaluating MSC injections, other regenerative approaches with and w/o stems cells even though I am very interested in these advance techniques in order to avoid TKR. So, for me -- the input from certain OS's I spoken to did called into question exactly this issue -- how much regeneration if at all, and their opinions did lead me to hold off seriously considering getting MSC injections immediately, and lead me to try simpler and lower cost PRP injections instead. And in my case -- I basically have realized the same level of painless-ness as you with PRP alone. This is not to discourage you, as all those stems cells you received are without doubt in your defective areas and are at work doing certain levels of repair for you. So, may be keep us posted at 1 year and perhaps by then you would have realized detectable amount of cartilage regeneration, especially if image was taken via MRI instead of X-Ray. Best of luck to you~!