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Author Topic: Arthrofibrosis Research Being Done Anywhere????  (Read 40247 times)

Offline Jill M

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #15 on: February 15, 2011, 08:07:22 PM »
Pam,
Thanks for all your hard work researching these articles. Very interesting.
Jill
8/07 Right subtotal meniscectomy
4/08 Chronic meniscus tear, grade 4 changes
10/08- R distal femoral osteotomy, lateral meniscal transplant, tibia microfracture, osteochondral allograft femur
12/08- AF noted, LOA
2/09- MUA
8/09- extensive LOA, patella baja
1/20/11- TKR

Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #16 on: February 16, 2011, 01:10:55 AM »
Some articles are repeated in the different lists previously posted, by the way great work :-)
I didn't posted other links myself because, as I said, all the articles related to researches arrive prety much to the same conclusion (see in my previous post in this thread the 2 best summarizing extract I believe are covering the whole thing).
This said, in the last list posted by Pam is possible to read some appendix of a research of the University of Pittsburgh here previoysly posted (and this is one of the 2 links I was talking about..), specifically the use of anti-fibrotic agent in experiments.
I'm trying to get a feedback via e-mail from the lead author of the above mentioned research, he's (or he was) working with a worldwide famous knee surgeon too (that's not in the "who's who in AF" list posted in this website, by the way), so I feel this could be a double resource (molecular genetist/researcher + knee orthopaedic surgeon) to understand if something can possibly be done on humans.
I'll keep you updated.
Today I saw a rheumatologist in my city in Europe (to try to start cosulting some specialist in this possible direction, it was worth to try as I get the app in few days and was 10 min away by car from my house..), he said nothing can be eventually be done because everything comes from the genetic predisposition patient by patient, this data are correct but no treatment are possible to avoid/reverse what described in the researches.
This said, we know (by reading the articles posted in this thread) that treatments are possible, mostly on animals, few on humans (at least, this is what I get), so I think it cost nothing going ahead and having a colsultation with the most updated researchers/doctors to see if something can be done in this direction.
Bye
Decruz

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Offline missmyknee

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #17 on: February 16, 2011, 02:37:23 AM »
Hi Decruz

Did you see this article in particular.......this seems closest to reality than most and specific to AF

Method for preventing scar tissue formation
http://www.patentstorm.us/patents/6060474/description.html

I said I might have done a couple duplicates.....some easier to read from a different source. There are anti-fibrotic agents out there being used for other fibrotic conditions of the body....and there are many, with worse prognoses than AF. Perhaps the 1% who get AF don't warrent any priority over those other more serious fibrotic conditions.

Pam

« Last Edit: April 12, 2012, 11:44:50 PM by missmyknee »
4Fx Clsd red
IMrod fib plate
derotate osteotmy tibfib
AF
IPCS patbaja
DeLeeOsteotmy,LOA,LR Zplasty,bongrf,chondrplty
chondrplty,LOA,fatpad remvd
TKR
openLOA,neurectmy,ITB Zplasty,fabela
PLC recon,revison,LOA,synovec
MCL,revison LOA
openLOA,prox Zplasty
openLOA, 6 neuromas excised,synov
3 Fusions

Offline Rennschnecke

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #18 on: February 16, 2011, 01:46:29 PM »
Hi Pam

On a global scale there are so many people with conditions which are disabling and who need treatment to improve their quality of life.

I haven't taken the time to review this area thoroughly (struggling just to do my proper research), but when treatments are developed they need to consider the risk factors if something goes wrong.  A conservative approach would be to start treatments on those who have least to use, hence the focus on those who have worse prognoses than those who have knee AF.

I don't think any Dr likes to provide treatment to a patient where they think there is a good likelihood of you ending up worse than before you started.  They prefer that we adapt as much as possible.

As far as I can tell, the people on this board are as knowledgeable as most about managing AF, and probably for the foreseeable future there is no simple treatment in sight to help us. :( 

But keeping in touch with the research can help to alert us to when trials progress to the clinical level.



1/05 Ski accident: 5/05 ACLr LK; 10/06 Scope – debridement, trochlear cartilage lesion (Gr4); 12/08 Scope – chondroplasty, hematoma; 5 & 6/09 MACI patella & trochlea 'kissing lesions', ROM 0 to 80; 9/09 Scope – LOA, IPCS & patella infera; 9/10 Scope – AIR & LR.

Offline missmyknee

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #19 on: February 16, 2011, 05:44:31 PM »
Hi Renn

The article I posted above you is using a drug already in use and the article posted below is one already done on humans. I also know that seprafilm has been used in the ortho setting for AF but mainly used in abdominal surgery to prevent adhesions. One of our former posters had the seprafilm done, but it did not work. His AF came back.
 
Clinical benefits of intra-articular anakinra for arthrofibrosis.
http://orthopedics.researchtoday.net/archive/6/12/3121.htm

I'm hoping that discoveries made to help other fibrosing conditions will be the key for AF. The whole cellular process of AF is very complicated and finding something that will affect all the cells involved will be difficult. If it was simple then there would be cures for fibrosis conditions such as, pulmonary fibrosis, crohns disease, liver fibrosis,etc..........

I also think a very important part of fighting AF would be to require ALL OS's to be certified in AF. That way everything is done to prevent it and if AF progresses, then catch it early to treat. Think of the patients who would retain their quality of life and the financial impact it would have, to not have that burden on patients and insurance. How many people on this website have the same story of, "My OS doesn't know, doesn't believe, waits too long, or gives up, in denial, or provides the wrong treatment".  It is a devastating complication of surgery and should rank up in the top 3 of complications , below DVT and infection.

With that said, a subset of people, like myself, have AF come back repeatedly ( 10yrs for me), even though all those measures are taken , including treatment from AF docs. It would help if there was an anti-fibrotic agent that could be routinely used, during surgery, or post-op. Just like injecting marcaine, or cortisone, before knee is closed.

BTW, Would you like to add the name of the doctor who treated you for AF, to the Who's Who list? If so let me know and I will put it in the list. Since Dr Strover is retiring, who is one that another poster a couple years ago, used with good results.

Pam
« Last Edit: April 12, 2012, 11:45:59 PM by missmyknee »
4Fx Clsd red
IMrod fib plate
derotate osteotmy tibfib
AF
IPCS patbaja
DeLeeOsteotmy,LOA,LR Zplasty,bongrf,chondrplty
chondrplty,LOA,fatpad remvd
TKR
openLOA,neurectmy,ITB Zplasty,fabela
PLC recon,revison,LOA,synovec
MCL,revison LOA
openLOA,prox Zplasty
openLOA, 6 neuromas excised,synov
3 Fusions

Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #20 on: February 16, 2011, 06:56:17 PM »
Hi Decruz

Did you see this article in particular.......this seems closest to reality than most and specific to AF

http://www.patentstorm.us/patents/6060474/description.html

Pam


Hi Pam,
yes I found too the article about using synthetic antibiotics already on the market interesting, but I'km having problems in getting e-mail address of the 2 authors, By the way if I get it right both are from Hospital for Special Surgery but one in NY and one in Greenwich, CT:


The articles authors are on the top of the page you posted, on the left under the title "Inventors", do you think too I got the right doctors (no mistakes with others with the same name..)?

I think we should find a way to get both their e-mail address, if not possible, call them...
I prefer e-mailing to better describe the case and because I'm on the other side of thre world..
Let me know if you find it, I'll try too...

About the use of intra-articular anakinra for arthrofibrosis you re-posted (http://orthopedics.researchtoday.net/archive/6/12/3121.htm), I asked the rheumathologist yesterday, he confirmed is an IL-1 antagonist drug used for rheumatoid arthritis, no longer on the market from at least 10 years in my country (but the research was published just in the 2010, so it doesn't mean nothing...), I dind't get a real answer other than that.



The thing is multiples researchers/doctors need to be contacted to see what can be done.
We can just divide them between us and keep contacting them until an answer is got, if someone of us is close can even go to a visit if possible and let us all now, I'll do the same myself - who's willing to share this with me?
Decruz

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Offline Rennschnecke

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #21 on: February 16, 2011, 06:58:11 PM »
Hi Pam

I know that some anti-fibrotic sheets have been used for abdominal surgery, but there is not yet approval for the knee.  There may simply be await to see how well the abdominal stuff goes before extending uses.  I could ask a friend about the likelihood of this being extended to knee treatments, but he's not an OS.

In the UK all OSs have to specialize, so we don't have a situation where there are general OS surgeons as far as I can tell from looking at the profile of OSs.  The OSs will have one or two joint specialities, e.g. knee or knee and hip.  All OSs in the UK will have basic training in AF and the treatments for these, mainly MUA for TKRs and arthroscopic releases.  However, some surgeons are so excellent at their work (e.g. my OS for my ACLr) that AF is rarely a complication.  That OS simply will not operate if the knee is inflamed etc. and basically follows all best practice.

I've not named the OS who treated me for AF as an AF specialist as strictly speaking he isn't.  He's a cartilage repair specialist and is the leading surgeon for meniscus replacement.  I don't know whether he would take on someone for AF surgery unless they were already a patient of his.  Normally, the current OS is expected to deal with any post-op complications including AF.  I think my OS would be happy to provide a second opinion, but I don't know whether he would treat someone for AF on this basis.  He might well then refer people back to their original OS so that he will be able to focus the majority of his time for his specialities.  Anyone who wants to ensure they see him for AF would probably have to arrange for a private appointment or they may be seen by other consultants.  However, the wait for an appointment with a referral backed up by prior conversations between OSs can still be 3 months. (My OS was expecting me to see him, but the earliest they could fit me in was just short of 3 months, but it wasn't for AF.)  If you have AF and have time constraints he may not be a good person to go to as he's in very high demand.

For those in the UK there are many good, competent OSs who can probably treat AF.  The only time a specialist might be need is when you have patella baja and IPCS.  My OS can do an AIR arthroscopically and I know that it is very rarely performed.  However, he's not an OS who does lots of these each year unlike Drs Millett, Steadman and Folk and others listed here for the US.  It's not done locally and my OS very rarely does this as well.  I believe that any OS in the UK involved with procedures that have a high incidence of AF despite best practice are the most likely to be able to offer the full range of procedures and I don't know if my OS is one of these.  Those named on the KG list would be a good start.  My own OS is on this list (but I didn't see him because of this).

In the UK the OS generally does the carpentry and care of the patient is in the hands of the PT or GP.  It's been said that seeing an OS is only a small part of the recovery from AF, the greater importance is seeing a suitable PT.  Unfortunately, unless you are local to my OS he would not be able to recommend a PT.  He is also a great advocate that a person needs to do their rehab locally either by the hospital (NHS) or private PT.  He was dead set against me staying locally for the early stages of rehab.  TBH the PTs I've seen have never advocated aggressive rehab, but some are so benign as to be useless. 

My OS also doesn't have a specific rehab protocol.  I've just taken some verbal advice from him and combined it with all the protocol information posted here.  Jake's is the most comprehensive.

So, in summary, I have not given my OS's name as an AF specialist because strictly speaking he isn't; he doesn't have a specific written protocol for rehab, just verbal instructions; he doesn't have a PT facility.  If after all this you feel it would be useful to name him I will do so, but don't want to mislead people into thinking that he'll be giving the same kind of care reported from the US specialists that have been named here.

Sorry, for the long posting ...
1/05 Ski accident: 5/05 ACLr LK; 10/06 Scope – debridement, trochlear cartilage lesion (Gr4); 12/08 Scope – chondroplasty, hematoma; 5 & 6/09 MACI patella & trochlea 'kissing lesions', ROM 0 to 80; 9/09 Scope – LOA, IPCS & patella infera; 9/10 Scope – AIR & LR.

Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #22 on: February 16, 2011, 08:31:02 PM »
What happens in association with arthrofibrosis appear very well clear by reading all the above posted articles: exaggerated healing response with hyper-production of healing tissue (scar tissue) due to erratic accumulation of fibrous tissue too rich in collagen, this excess of collagen is due to a disturbance in the balance between matrix synthesis and matrix degradation, resulting from increased fibroblast metabolism and proliferation; all this process upstream regulated by the control of tranforming growth factor (TGF-ß1) identified by reaearchers as the key to fibrosis, that become highly out of control (score level in the body extremely higher than normal).
Besides, out of control cytokines in the IL-1 family are the principal alterated mediators of the hyper-inflammatory response associated with AF.

Later I'll post a list of the articles exclusively in relation to anti-fibrotic treatments, dividing them between already tested on animals and on humans - this to focus on these ones with the target to contact their authors.

Bye
Decruz

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Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #23 on: February 16, 2011, 11:36:32 PM »
Hi,
for who's interested in working together in researching all the available anti-fibrotic therapies/treatments and actively contacting the authors of these ones, please contact me privately through my e-mail address dcrzk@aol.com or via kneeguru's private messaging.
Once we'll create a little group we'll organize ourself, considering where we live, time available, other factors, to actually get feedbacks...
Thank u
Decruz

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Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #24 on: February 18, 2011, 01:04:36 AM »
Interesting: treatments on humans in Geneva, Switzerland (http://www.fasebj.org/content/early/2006/03/01/fj.05-4870fje.short) - one treatment with a lot of combined effects all positive as anti-fibrotic treatment

I'm filling a file.doc with all the classified articles/researches, I'd like to post it here but I'll be a very very long post (the doc is not finished yet and is already made by 7 pages...), maybe is better if I just post the list of classified researches only regarding actual treatments (not studies about the biochimical changes related to AF).

See you later
Decruz

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Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #25 on: February 18, 2011, 03:17:39 AM »
Hi everybody,
here below the classified articles about researches on TREATMENTS already tested on animals and/or humans and/or in lab.
I classified them with title, link, type (what's about), related authors, contact (phone, mail and e-mail), related links (that I found searching a bit on authors, departments, etc. - sometimes I found resources about some authors and others not, eg: 5 authors of the same research, only 1 link to 1 author profile added because I wasn't able to find others, or I was unsure due to possible homonymies or change of facility) and location (where in the world the research was done):


Article/research: Researchers cut fibrosis formation, increase muscle strength after injury
Link: http://www.orthosupersite.com/view.aspx?rid=3885
Type: biochemical AF process + possible treatments
Related authors: Li Y, Fu FH, Huard J, Wei Shen MD
Contact: Johnny Huard, PhD – Director Stem Cell Research Center, Bridgeside Point II Bldg, Suite 206, 450 Technology Drive, Pittsburgh, PA 15219 - Tel. 412-648-2798 (O), Fax 412-648-4066, e-mail: Jhuard@pitt.edu
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: University of Pittsburgh, USA

 
Article/research: The Use of Suramin, an Antifibrotic Agent, to Improve Muscle Recovery After Strain Injury
Link: http://ajs.sagepub.com/content/33/1/43.abstract
Type: treatments in lab
Related authors: Yi-Sheng Chan, MD, PhD, Yong Li, MD, PhD, William Foster, Freddie H. Fu, MD and Johnny Huard, PhD
Contact: Johnny Huard, PhD, University of Pittsburgh, Department of Orthopaedic Surgery, Children’s Hospital of Pittsburgh, 3460 Fifth Avenue, 4100 Rangos Research Center, Pittsburgh, PA 15213 (e-mail:jhuard@pitt.edu)
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
 

Article/research: Antifibrotic effects of suramin in injured skeletal muscle after laceration
Link: http://jap.physiology.org/content/95/2/771.full
Type: treatments in lab
Related authors: Yi-Sheng Chan, MD, PhD, Yong Li, MD, PhD, William Foster, Freddie H. Fu, MD and Johnny Huard, PhD, Takashi Horaguchi, George Somogyi
Contact: Johnny Huard, PhD, University of Pittsburgh, Department of Orthopaedic Surgery, Children’s Hospital of Pittsburgh, 3460 Fifth Avenue, 4100 Rangos Research Center, Pittsburgh, PA 15213 (e-mail:jhuard@pitt.edu)
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: Department of Orthopaedic Surgery, Growth and Development Laboratory, Children's Hospital of Pittsburgh and University of Pittsburgh, Department of Orthopaedic Surgery, Division of Sports Medicine, Musculoskeletal Research Center, University of Pittsburgh, Departments of Pharmacology and Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213; and Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Kueishan, Taoyuan, Taiwan.
 

Article/research: Using decorin, an anti-fibrosis agent, to improve muscle recovery after injury
Link: http://www.sportsinjurybulletin.com/archive/decorin.htm
Type: treatments on animals
Related authors: researchers of the University of Pittsburgh (probably Dr.Huard)
Contact: probably jhuard@pitt.edu
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: University of Pittsburgh
 

Article/research: The Use of Relaxin Improves Healing in Injured Muscle
Link: http://onlinelibrary.wiley.com/doi/10.1196/annals.1282.060/abstract
Type: treatments (on humans?)
Related authors: Y LI, S NEGISHI, M SAKAMOTO, A USAS, J HUARD
Contact: Johnny Huard, PhD, University of Pittsburgh, Department of Orthopaedic Surgery, Children’s Hospital of Pittsburgh, 3460 Fifth Avenue, 4100 Rangos Research Center, Pittsburgh, PA 15213 (e-mail:jhuard@pitt.edu)
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
 

Article/research: Muscle injuries and repair - current trends in research
Link: http://www.thiagovilelalemos.com.br/downloads/musculo/Muscle%20injuries%20and%20repair.pdf
Type: biochemical AF process + possible treatments
Related authors: Yong Li, MD, PhD, Freddie H. Fu, MD and Johnny Huard, PhD
Contact: Johnny Huard, PhD, University of Pittsburgh, Department of Orthopaedic Surgery, Children’s Hospital of Pittsburgh, 3460 Fifth Avenue, 4100 Rangos Research Center, Pittsburgh, PA 15213 (e-mail:jhuard@pitt.edu)
Related links: http://www.scrc.pitt.edu/, http://path.upmc.edu/cmp/fac62.htm, http://www.upmc.com/MEDIARELATIONS/EXPERTS/Pages/expertspage.aspx?expertid=86
Location: Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania


Article/research: Clinical Benefits of Intra-articular Anakinra for Arthrofibrosis
Link: http://www.orthosupersite.com/view.aspx?rid=77608 or http://orthopedics.researchtoday.net/archive/6/12/3121.htm
Type: treatments on humans
Related authors: Christopher A. Brown, MD; Alison P. Toth, MD; Bob Magnussen, MD
Contact: Christopher A. Brown, MD, Department of Orthopedic Surgery, Duke University Medical Center, Box 3970, 200 Trent Dr, Durham, NC 27710 (christopher.a.brown@duke.edu)
Related links: http://www.dukehealth.org/physicians/alison_p_toth
Location: Duke University Medical Center, Durham, North Carolina


Article/research: Halofuginone: a novel antifibrotic therapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/9522159
Type: treatments on animals
Related authors: Pines M, Nagler A.
Contact: NOT FOUND
Related links: NOT SEARCHED
Location: Institute of Animal Science, Volcani Center, Bet Dagan, Israel


Article/research: Selective inhibition of activin receptor–like kinase 5 signaling blocks profibrotic transforming growth factor β responses in skin fibroblasts
Link: http://onlinelibrary.wiley.com/doi/10.1002/art.20658/full
Type: treatments in lab
Related authors: Yasuji Mori, Wataru Ispida, Swati Bhattacharyya,,Yongzhong Li, Leonidas C. Platanias, John Varga.
Contact: John Varga, Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Street, McGaw 2300, Chicago, IL 60611-2909, Email: J-Varga@northwestern.edu.
Related links: NOT SEARCHED
Location: University of Illinois College of Medicine, Chicago - Northwestern University School of Medicine, Chicago, Illinois


Article/research: Pirfenidone: A Novel Potential Therapeutic Agent in the Management of Chronic Allograft Rejection / Anti-fibrotic agent with a potential therapeutic role in the management of transplantation patients
Link: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VJ0-4PPNW70-12&_user=10&_origUdi=B6T1J-4JGGD8S-3&_fmt=high&_coverDate=09/30/2007&_rdoc=1&_orig=article&_origin=article&_zone=related_art&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=53634d13f03d9d0e53a7479ce4eae2b5 and http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-4JGGD8S-3&_user=10&_coverDate=05/01/2006&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1646160536&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=76b3f7304d3d84b90216cd88c6ad9586&searchtype=a
Type: treatments in lab
Related authors: A. Dosanjh
Contact: NOT FOUND
Related links: NOT SEARCHED
Location: UCSD School of Medicine, La Jolla, California


Article/research: Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts
Link: http://www.fasebj.org/content/early/2006/03/01/fj.05-4870fje.short
Type: treatments on humans
Related authors: Fineschi S, Reith W, Guerne PA, Dayer JM, Chizzolini C.
Contact: Carlo Chizzolini, Immunology & allergy, Geneva University Hospital, 1211 Geneva 14, Switzerland – email: chizzolini@medicine.unige.ch
Related links: http://immunologie-allergologie.hug-ge.ch/recherche/groupe-chizzolini.html
Location: Immunology & allergy, Dep, of Internal Medicine, Dep. Of Pathology & Immunology, Rheumathology, Geneva University Hospital - Switzerland


Article/research: Use of the class of synthetic antibiotics known as fluoroquinolones to effectively inhibit scar tissue formation or reduce preexisting scar tissue
Link: http://www.patentstorm.us/patents/6060474/description.html
Type: treatments on humans
Related authors: Riley J. Williams, Hannafin, Jo A.
Contact: (see related links below)
Related links: http://www.hss.edu/physicians_williams-riley.asp, http://www.hss.edu/physicians_hannafin-jo.asp
Location: Hospital for Special Surgery NY & Greenwich, CT


Article/research: Gene delivery of TGF-beta1 induces arthrofibrosis and chondrometaplasia of synovium in vivo
Link: http://www.bioportfolio.com/resources/pmarticle/41343/Gene-Delivery-Of-Tgf-beta1-Induces-Arthrofibrosis-And-Chondrometaplasia-Of-Synovium-In.html
Type: treatments on animals
Related authors: NOT FOUND
Contact: NOT FOUND
Location: Department of Orthopaedics and Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA


Article/research: Halofuginone, a novel antifibrotic therapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/9522159
Type: treatments on animals
Related authors: Pines M, Nagler A.
Contact: NOT SEARCHED
Related links: NOT SEARCHED
Location: Institute of Animal Science, Volcani Center, Bet Dagan, Israel


Article/research: Scar Tissue – Radiation and Enzyme Studies to Prevent Spinal Scar Tissue
Link: http://www.scar-tissue.biz/scar-tissue-%E2%80%93-radiation-and-enzyme-studies-to-prevent-spinal-scar-tissue/
Type: treatments on animals & humans (NO LONGER AVAILABLE)
Related authors: NOT FOUND
Contact: NOT FOUND
Related links: NOT FOUND
Location: University NOT FOUND


Article/research: Collagen Fibril Formation, A NEW TARGET TO LIMIT FIBROSIS
Link: http://ukpmc.ac.uk/articles/PMC2533774
Type: treatments in lab & on animals
Related authors: Li Hye Jin Chung, Andrzej Steplewski, Kee Yang Chung, Jouni Uitto and Andrzej Fertala
Contact: Dept. of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, BLSB, Rm. 424, 233 S. 10th St., Philadelphia, PA 19107. Tel.: 215-503-0113; Fax: 215-503-5788; E-mail: andrzej.fertala@jefferson.edu
Related links: NOT SEARCHED
Location: Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 and §Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, 120-752, South Korea


Article/research: Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis
Link: http://ukpmc.ac.uk/abstract/MED/17323096
Type: treatments on humans
Related authors: Everts PA, Devilee RJ, Oosterbos CJ, Mahoney CB, Schattenkerk ME, Knape JT, van Zundert A
Contact: everts@elive.nl
Related links: NOT SEARCHED
Location: Department of Peri-Operative Blood Management, Catharina Hospital, Eindhoven, The Netherlands


Article/research: Novel use of botulinum toxin to ameliorate arthrofibrosis: an experimental study in rabbits
Link: http://ukpmc.ac.uk/abstract/MED/17763285
Type: treatments on animals
Related authors: Namazi H, Torabi S
Contact: Namazih@sums.ac.ir
Related links: NOT SEARCHED
Location: Shiraz University of Medical Sciences, Shiraz, Iran


Article/research: Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art
Link: http://ukpmc.ac.uk/articles/PMC2805599 or http://www.fibrogenesis.com/content/2/1/7 or http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805599/
Type: biochemical AF process + treatments in lab
Related authors: Clarice ZC Chen and Michael Raghunath
Contact: clarice@nus.edu.sg, bierm@nus.edu.sg
Related links: NOT SEARCHED
Location: Division of Bioengineering, Faculty of Engineering, National University of Singapore, DSO Building (Kent Ridge), Medical Drive, Singapore - NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore - Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore





PS: sometimes I didn't search other related links because the treatment sounded to me at the first stage or far to be even "thinkable" on humans, for sure the searching on the net needs to be extended.
I needed to classify for myself the more available resources (there's still a lot on the net, by the way..) in order to understand who should be contacted and where the most advanced researchers are located.
Eg: you can see that multiples treatments, on animals/humans or in lab, were developed by the same groups of researchers/doctors in the same places, consequently assuming that they and their facilities are the people/place to contact if searching for the most updated resources in this field.
I'd be great if you could add resources, such as links on authors/facilities I wasn't able to find, to enrich the list with useful details.
Thank you
Bye
Decruz

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Offline missmyknee

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #26 on: February 19, 2011, 04:57:48 AM »
Hi Decruz

Nice job organizing the articles.

I found the whole article regarding Perfinidone. Here it is

The multifaceted role of pirfenidone and its novel targets
http://www.fibrogenesis.com/content/3/1/16

Here is another full article, which might duplicate info, but is probably the most complete article describing the cellular process and all the cells involved in detail

Cell-matrix interactions in dermal repair and scarring
http://www.fibrogenesis.com/content/3/1/4

Here are 3 excellent websites. Look all thru them !

http://www.promedior.com/about/index.html

Promedior Initiates Clinical Study of Anti-Fibrotic Therapeutic, PRM-151, in Patients with Idiopathic Pulmonary Fibrosis (IPF)
Promedior Inc.Posted on:10 Feb 11
http://www.pharmiweb.com/pressreleases/pressrel.asp?ROW_ID=35633#ixzz1rrxdnQQo

These next 2 sites are very important
      
Anti-Fibrotic Drug Experts
http://www.intota.com/experts.asp?strSearchType=all&strQuery=anti-fibrotic+drug    and

Anti-fibrotic medicament
http://www.patsnap.com/patents/view/US5993845.html

Here is a link to all sorts of journals that provide open access to full articles

http://www.biomedcentral.com/browse/bysubject/

Some other articles

ANTIFIBROTIC AGENT
http://www.wikipatents.com/CA-Patent-2259773/antifibrotic-agent

Anti-Fibrotic Data from Amira Pharmaceuticals’ LPA1 Receptor Antagonist Program Published in the British Journal of Pharmacology
http://www.evaluatepharma.com/Universal/View.aspx?type=Story&id=213050

Criteria to select molecular targets for anti-fibrotic therapy
http://rheumatology.oxfordjournals.org/content/47/suppl_5/v12.full

Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis
http://www.fibrogenesis.com/content/3/1/24

The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair
http://www.nature.com/jid/journal/v127/n5/full/5700811a.html

Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty
http://www.fibrogenesis.com/content/2/1/5

Here is a list of doctors who gave presentations at this conference on fibrosis in 2007

Molecular Mechanisms of Fibrosis: From Bench to Bedside (C5)
http://www.keystonesymposia.org/Meetings/ViewPastMeetings.cfm?MeetingID=851

Pam
« Last Edit: April 13, 2012, 12:04:45 AM by missmyknee »
4Fx Clsd red
IMrod fib plate
derotate osteotmy tibfib
AF
IPCS patbaja
DeLeeOsteotmy,LOA,LR Zplasty,bongrf,chondrplty
chondrplty,LOA,fatpad remvd
TKR
openLOA,neurectmy,ITB Zplasty,fabela
PLC recon,revison,LOA,synovec
MCL,revison LOA
openLOA,prox Zplasty
openLOA, 6 neuromas excised,synov
3 Fusions

Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #27 on: February 19, 2011, 06:49:38 PM »
Probably not posted yet (but again, all the articles/researches about the biochemical changes related to AF pretty much come to the same conclusions, so once you got the concept...):



Article/research: Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140013/?tool=pubmed
Type: biochemical AF process
Related authors: Pierre-Jean Wipff, Daniel B. Rifkin, Jean-Jacques Meister, and Boris Hinz
Contact: B. Hinz: boris.hinz@epfl.ch
Related links: http://ipmc.epfl.ch/page8761.html,
Location: Laboratory of Cell Biophysics, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland, Department of Cell Biology, New York University School of Medicine, New York, NY 10016


Article/research: Interactions between extracellular matrix and growth factors in wound healing
Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00466.x/full
Type: biochemical AF process
Related authors: Gregory S. Schultz PhD, Annette Wysocki PhD
Contact: Gregory S. Schultz, PhD, Department of Obstetrics and Gynecology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0294. Tel: +352 273 7560; Fax: +352 392 6994; Email: schultzg@ufl.edu
Related links: NOT SEARCHED
Location: Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, and School of Nursing and Department of Surgery, University of Mississippi Medical Center, Jackson, Mississippi


Bye
Decruz

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Offline missmyknee

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  • From the Land of OZ
Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #28 on: February 22, 2011, 05:50:39 PM »
Hi All

I've asked Sheila/KNEEGuru to lock this thread in place at the top of this section. This way it's easier to keep adding to it and to provide easy access to ongoing information.

Thanks KNEEguru   ;D    and to Patty, for creating this thread  ;D

Pam
4Fx Clsd red
IMrod fib plate
derotate osteotmy tibfib
AF
IPCS patbaja
DeLeeOsteotmy,LOA,LR Zplasty,bongrf,chondrplty
chondrplty,LOA,fatpad remvd
TKR
openLOA,neurectmy,ITB Zplasty,fabela
PLC recon,revison,LOA,synovec
MCL,revison LOA
openLOA,prox Zplasty
openLOA, 6 neuromas excised,synov
3 Fusions

Offline Decruz

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Re: Arthrofibrosis Research Being Done Anywhere????
« Reply #29 on: February 23, 2011, 12:53:28 AM »
Well done...
Bye
Decruz

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